Article
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
Nature genetics - 6 Nov 2011
Trynka Gosia, Hunt Karen A, Bockett Nicholas A, Romanos Jihane, Mistry Vanisha, Szperl Agata, Bakker Sjoerd F, Bardella Maria Teresa, Bhaw-Rosun Leena, Castillejo Gemma, de la Concha Emilio G, de Almeida Rodrigo Coutinho, Dias Kerith-Rae M, van Diemen Cleo C, Dubois Patrick C A, Duerr Richard H, Edkins Sarah, Franke Lude, Fransen Karin, Gutierrez Javier, Heap Graham A R, Hrdlickova Barbara, Hunt Sarah, Plaza Izurieta Leticia, Izzo Valentina, Joosten Leo A B, Langford Cordelia, Mazzilli Maria Cristina, Mein Charles A, Midah Vandana, Mitrovic Mitja, Mora Barbara, Morelli Marinita, Nutland Sarah, Núñez Concepción, Onengut-Gumuscu Suna, Pearce Kerra, Platteel Mathieu, Polanco Isabel, Potter Simon, Ribes-Koninckx Carmen, Ricaño-Ponce Isis, Rich Stephen S, Rybak Anna, Santiago José Luis, Senapati Sabyasachi, Sood Ajit, Szajewska Hania, Troncone Riccardo, Varadé Jezabel, Wallace Chris, Wolters Victorien M, Zhernakova Alexandra, Thelma B K, Cukrowska Bozena, Urcelay Elena, Bilbao Jose Ramon, Mearin M Luisa, Barisani Donatella, Barrett Jeffrey C, Plagnol Vincent, Deloukas Panos, Wijmenga Cisca, van Heel David A
Abstract excerpt
Using variants from the 1000 Genomes Project pilot European CEU dataset and data from additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls. We identified 13 new celiac disease risk loci reaching genome-wide significance, bringing the number of known loci (including the...
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