Article
Understanding Celiac Disease by Genomics.
Trends in genetics : TIG - 1 May 2016
Withoff Sebo, Li Yang, Jonkers Iris, Wijmenga Cisca
Abstract excerpt
Celiac disease (CeD) is a complex immune-mediated disease. Genetic studies have implicated 43 predisposing loci that collectively explain some 50% of the genetic variance in CeD. More than ∼90% of CeD-associated single nucleotide polymorphisms (SNPs) localize to the non-coding genome, which we need to better understand to translate genetic knowledge into clinical practice. New genomic technologies and resources...
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