A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.

doi:10.1038/ng.3020

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Article

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.

Nature genetics - 1 Aug 2014

Fachal Laura, Gómez-Caamaño Antonio, Barnett Gillian C, Peleteiro Paula, Carballo Ana M, Calvo-Crespo Patricia, Kerns Sarah L, Sánchez-García Manuel, Lobato-Busto Ramón, Dorling Leila, Elliott Rebecca M, Dearnaley David P, Sydes Matthew R, Hall Emma, Burnet Neil G, Carracedo Ángel, Rosenstein Barry S, West Catharine M L, Dunning Alison M, Vega Ana

Abstract excerpt

There is increasing evidence supporting the role of genetic variants in the development of radiation-induced toxicity. However, previous candidate gene association studies failed to elucidate the common genetic variation underlying this phenotype, which could emerge years after the completion of treatment. We performed a genome-wide association study on a Spanish cohort of 741 individuals with prostate cancer...

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PMID: 24974847
DOI: 10.1038/ng.3020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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