A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.

doi:10.1016/j.radonc.2014.02.012

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Article

A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 May 2014

Barnett Gillian C, Thompson Deborah, Fachal Laura, Kerns Sarah, Talbot Chris, Elliott Rebecca M, Dorling Leila, Coles Charlotte E, Dearnaley David P, Rosenstein Barry S, Vega Ana, Symonds Paul, Yarnold John, Baynes Caroline, Michailidou Kyriaki, Dennis Joe, Tyrer Jonathan P, Wilkinson Jennifer S, Gómez-Caamaño Antonio, Tanteles George A, Platte Radka, Mayes Rebecca, Conroy Don, Maranian Mel, Luccarini Craig, Gulliford Sarah L, Sydes Matthew R, Hall Emma, Haviland Joanne, Misra Vivek, Titley Jennifer, Bentzen Søren M, Pharoah Paul D P, Burnet Neil G, Dunning Alison M, West Catharine M L

Abstract excerpt

BACKGROUND AND PURPOSE: This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity 2years after radiotherapy. MATERIALS AND METHODS: A genome wide association study was performed in 1850 patients from the RAPPER study: 1217 received adjuvant breast radiotherapy and 633 had radical prostate radiotherapy. Genotype associations with both overall and individual...

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Identifiers

PMID: 24785509
DOI: 10.1016/j.radonc.2014.02.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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