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Article

XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients.

International journal of radiation oncology, biology, physics - 1 Aug 2015

Seibold Petra, Behrens Sabine, Schmezer Peter, Helmbold Irmgard, Barnett Gillian, Coles Charlotte, Yarnold John, Talbot Christopher J, Imai Takashi, Azria David, Koch C Anne, Dunning Alison M, Burnet Neil, Bliss Judith M, Symonds R Paul, Rattay Tim, Suga Tomo, Kerns Sarah L, Bourgier Celine, Vallis Katherine A, Sautter-Bihl Marie-Luise, Claßen Johannes, Debus Juergen, Schnabel Thomas, Rosenstein Barry S, Wenz Frederik, West Catharine M, Popanda Odilia, Chang-Claude Jenny

Abstract excerpt

PURPOSE: To identify single-nucleotide polymorphisms (SNPs) in oxidative stress-related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy. METHODS AND MATERIALS: Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes...

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Breast
Fibrosis
Germany
Oxidative Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Radiation Injuries

Radiation Tolerance

X-ray Repair Cross Complementing Protein 1

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Identifiers

PMID: 26072091
DOI: 10.1016/j.ijrobp.2015.04.011

Genes

XRCC1

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