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Article

Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2009

Pugh Trevor J, Keyes Mira, Barclay Lorena, Delaney Allen, Krzywinski Martin, Thomas Dallas, Novik Karen, Yang Cindy, Agranovich Alexander, McKenzie Michael, Morris W Jim, Olive Peggy L, Marra Marco A, Moore Richard A

Abstract excerpt

PURPOSE: The presence of intrinsic radiosensitivity within prostate cancer patients may be an important factor contributing to development of radiation toxicity. We investigated whether variants in genes responsible for detecting and repairing DNA damage independently contribute to toxicity following prostate brachytherapy. EXPERIMENTAL DESIGN: Genomic DNA was extracted from blood samples of 41 prostate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19638463
DOI: 10.1158/1078-0432.CCR-08-3357

Genes

ATM
LIG4
MDC1
BRCA1
ERCC2
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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