Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study.

doi:10.1016/S1470-2045(11)70302-3

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Article

Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study.

The Lancet. Oncology - 1 Jan 2012

Barnett Gillian C, Coles Charlotte E, Elliott Rebecca M, Baynes Caroline, Luccarini Craig, Conroy Don, Wilkinson Jennifer S, Tyrer Jonathan, Misra Vivek, Platte Radka, Gulliford Sarah L, Sydes Matthew R, Hall Emma, Bentzen Søren M, Dearnaley David P, Burnet Neil G, Pharoah Paul D P, Dunning Alison M, West Catharine M L

Abstract excerpt

BACKGROUND: Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset. METHODS: 92 (of 98 attempted) SNPs in 46 genes were successfully...

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PMID: 22169268
DOI: 10.1016/S1470-2045(11)70302-3

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