Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila.

doi:10.1042/BJ20130923

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Article

Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila.

The Biochemical journal - 1 Sept 2014

Riedmaier Patrice, Sansom Fiona M, Sofian Trifina, Beddoe Travis, Schuelein Ralf, Newton Hayley J, Hartland Elizabeth L

Abstract excerpt

Legionella pneumophila is an opportunistic pathogen that replicates within alveolar macrophages resulting in the onset of severe atypical pneumonia. Previously we have identified Lpg1905, a eukaryotic-type ecto-NTPDase (nucleoside triphosphate diphosphohydrolase) from L. pneumophila that was required for optimal intracellular replication and virulence in a mouse lung infection model. In the present study, we...

Topics

Adenosine Triphosphatases
Adenosine Triphosphate
Animals
Antigens, CD
Apyrase
Bacterial Proteins
Calcium
Cations, Divalent
Cell Line
Female
Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydrogen-Ion Concentration

Hydrolysis

Legionella pneumophila

Legionnaires' Disease

Macrophages

Magnesium

Source

Open in PubMed

Identifiers

PMID: 24957128
DOI: 10.1042/BJ20130923

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Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila.PMID 24957128Read ↗

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