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Article

Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole.

PLoS pathogens - 1 May 2006

Weber Stefan S, Ragaz Curdin, Reus Katrin, Nyfeler Yves, Hilbi Hubert

Abstract excerpt

The causative agent of Legionnaires' disease, Legionella pneumophila, employs the intracellular multiplication (Icm)/defective organelle trafficking (Dot) type IV secretion system (T4SS) to upregulate phagocytosis and to establish a replicative vacuole in amoebae and macrophages. Legionella-containing vacuoles (LCVs) do not fuse with endosomes but recruit early secretory vesicles. Here we analyze the role of host...

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Source

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Identifiers

PMID: 16710455
DOI: 10.1371/journal.ppat.0020046
PMCID: PMC1463015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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