Article
Deletion of potD, encoding a putative spermidine-binding protein, results in a complex phenotype in Legionella pneumophila.
International journal of medical microbiology : IJMM - 1 Jul 2014
Nasrallah Gheyath K, Abdelhady Hany, Tompkins Nicholas P, Carson Kaitlyn R, Garduño Rafael A
Abstract excerpt
L. pneumophila is an intracellular pathogen that replicates in a membrane-bound compartment known as the Legionella-containing vacuole (LCV). We previously observed that the polyamine spermidine, produced by host cells or added exogenously, enhances the intracellular growth of L. pneumophila. To study this enhancing effect and determine whether polyamines are used as nutrients, we deleted potD from L. pneumophila...
Topics
- Gene Deletion
- Legionella pneumophila
- Periplasmic Binding Proteins
- Phenotype
- Spermidine