A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila.

doi:10.1111/j.1462-5822.2007.00924.x

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Article

A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila.

Cellular microbiology - 1 Aug 2007

Sansom Fiona M, Newton Hayley J, Crikis Sandra, Cianciotto Nicholas P, Cowan Peter J, d'Apice Anthony J F, Hartland Elizabeth L

Abstract excerpt

As part of its pathogenesis, Legionella pneumophila persists within human alveolar macrophages in non-acidified organelles that do not mature into phagolysosomes. Two L. pneumophila genes, lpg0971 and lpg1905, are predicted to encode ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases) that share sequence similarity with human CD39/NTPDase1. The predicted products possess five apyrase conserved...

Topics

Adenosine Triphosphatases
Amino Acid Sequence
Animals
Antigens, CD
Apyrase
Bacterial Proteins
Biological Transport, Active
Cell Line
Computational Biology
Epithelial Cells
Hartmannella
Humans
In Vitro Techniques

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Legionella pneumophila

Molecular Sequence Data

Monocytes

Mutation

Platelet Aggregation

Source

Open in PubMed

Identifiers

PMID: 17388784
DOI: 10.1111/j.1462-5822.2007.00924.x

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