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A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila.

Cellular microbiology - 1 Aug 2007

Sansom Fiona M, Newton Hayley J, Crikis Sandra, Cianciotto Nicholas P, Cowan Peter J, d'Apice Anthony J F, Hartland Elizabeth L

Abstract excerpt

As part of its pathogenesis, Legionella pneumophila persists within human alveolar macrophages in non-acidified organelles that do not mature into phagolysosomes. Two L. pneumophila genes, lpg0971 and lpg1905, are predicted to encode ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases) that share sequence similarity with human CD39/NTPDase1. The predicted products possess five apyrase conserved...

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PMID: 17388784
DOI: 10.1111/j.1462-5822.2007.00924.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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