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Article

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.

The Journal of biological chemistry - 9 May 2008

Sansom Fiona M, Riedmaier Patrice, Newton Hayley J, Dunstone Michelle A, Müller Christa E, Stephan Holger, Byres Emma, Beddoe Travis, Rossjohn Jamie, Cowan Peter J, d'Apice Anthony J F, Robson Simon C, Hartland Elizabeth L

Abstract excerpt

Legionella pneumophila is the predominant cause of Legionnaires disease, a severe and potentially fatal form of pneumonia. Recently, we identified an ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) from L. pneumophila, termed Lpg1905, which enhances intracellular replication of L. pneumophila in eukaryotic cells. Lpg1905 is the first prokaryotic member of the CD39/NTPDase1 family of enzymes, which are...

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PMID: 18337253
DOI: 10.1074/jbc.M801006200
PMCID: PMC2442346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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