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Article

Molecular disruption of the power stroke in the ATP-binding cassette transport protein MsbA.

The Journal of biological chemistry - 8 Mar 2013

Doshi Rupak, Ali Anam, Shi Wilma, Freeman Elizabeth V, Fagg Lisa A, van Veen Hendrik W

Abstract excerpt

ATP-binding cassette transporters affect drug pharmacokinetics and are associated with inherited human diseases and impaired chemotherapeutic treatment of cancers and microbial infections. Current alternating access models for ATP-binding cassette exporter activity suggest that ATP binding at the two cytosolic nucleotide-binding domains provides a power stroke for the conformational switch of the two membrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23306205
DOI: 10.1074/jbc.M112.430074
PMCID: PMC3591591

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