Structural basis for the mechanism of ABC transporters.

Abstract excerpt

The ATP-binding cassette (ABC) transporters are primary transporters that couple the energy stored in adenosine triphosphate (ATP) to the movement of molecules across the membrane. ABC transporters can be divided into exporters and importers; importers mediate the uptake of essential nutrients into cells and are found predominantly in prokaryotes whereas exporters transport molecules out of cells or into...

Topics

• ATP-Binding Cassette Transporters
• Adenosine Triphosphatases
• Animals
• Biocatalysis
• Biological Transport, Active
• Drug Resistance, Multiple
• Humans
• Isoenzymes
• Models, Molecular
• Mutation
• Protein Conformation
• Protein Isoforms
• Protein Structure, Tertiary