Article
Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Circulation. Cardiovascular genetics - 1 Jun 2014
Bis Joshua C, White Charles C, Franceschini Nora, Brody Jennifer, Zhang Xiaoling, Muzny Donna, Santibanez Jireh, Gibbs Richard, Liu Xiaoming, Lin Honghuang, Boerwinkle Eric, Psaty Bruce M, North Kari E, Cupples L Adrienne, O'Donnell Christopher J
Abstract excerpt
BACKGROUND: Atherosclerosis, the precursor to coronary heart disease and stroke, is characterized by an accumulation of fatty cells in the arterial intimal-medial layers. Common carotid intima media thickness (cIMT) and plaque are subclinical atherosclerosis measures that predict cardiovascular disease events. Previously, genome-wide association studies demonstrated evidence for association with cIMT (SLC17A4)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.