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Article

Exploring the causal biological association between mitochondrial genes and carotid plaques: A multiomics Mendelian randomization study.

Atherosclerosis - 1 Feb 2026

Yu Zhuyuan, Meng Xiangyuan, Zong Ziyu, Song Qi, Huo Yingchao, Chen Hao

Abstract excerpt

BACKGROUND: To investigate the causal relationship between mitochondrial genes and the pathogenesis of carotid plaque (CP), a multiomics-integrated Mendelian randomization (MR) analysis was performed in this study. METHODS: Leveraging data from the McRae study, UK Biobank, eQTLGen Consortium, and decode database, we extracted mitochondrial gene QTLs at methylation, gene expression, and protein abundance levels as...

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Share to Carotid Artery Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Mitochondrial

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Share to Plaque, Atherosclerotic

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Source

Identifiers

PMID: 41548323
DOI: 10.1016/j.atherosclerosis.2025.120570

Genes

CP
GATM
ACAT1
ACSM2A
AGXT
CBR4
CKMT2
GRHPR
METAP1D
NIT2
PGS1
PTPMT1
SDSL
SLC25A28
SPRYD4
TARS2
TOP1MT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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