Article
Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Circulation. Cardiovascular genetics - 1 Jun 2014
Lin Honghuang, Wang Min, Brody Jennifer A, Bis Joshua C, Dupuis Josée, Lumley Thomas, McKnight Barbara, Rice Kenneth M, Sitlani Colleen M, Reid Jeffrey G, Bressler Jan, Liu Xiaoming, Davis Brian C, Johnson Andrew D, O'Donnell Christopher J, Kovar Christie L, Dinh Huyen, Wu Yuanqing, Newsham Irene, Chen Han, Broka Andi, DeStefano Anita L, Gupta Mayetri, Lunetta Kathryn L, Liu Ching-Ti, White Charles C, Xing Chuanhua, Zhou Yanhua, Benjamin Emelia J, Schnabel Renate B, Heckbert Susan R, Psaty Bruce M, Muzny Donna M, Cupples L Adrienne, Morrison Alanna C, Boerwinkle Eric
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified thousands of genetic variants that influence a variety of diseases and health-related quantitative traits. However, the causal variants underlying the majority of genetic associations remain unknown. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study aims to follow up genome-wide association study...
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