Article
Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk.
Circulation. Cardiovascular genetics - 1 Dec 2012
Gertow Karl, Sennblad Bengt, Strawbridge Rona J, Ohrvik John, Zabaneh Delilah, Shah Sonia, Veglia Fabrizio, Fava Cristiano, Kavousi Maryam, McLachlan Stela, Kivimäki Mika, Bolton Jennifer L, Folkersen Lasse, Gigante Bruna, Leander Karin, Vikström Max, Larsson Malin, Silveira Angela, Deanfield John, Voight Benjamin F, Fontanillas Pierre, Sabater-Lleal Maria, Colombo Gualtiero I, Kumari Meena, Langenberg Claudia, Wareham Nick J, Uitterlinden André G, Gabrielsen Anders, Hedin Ulf, Franco-Cereceda Anders, Nyyssönen Kristiina, Rauramaa Rainer, Tuomainen Tomi-Pekka, Savonen Kai, Smit Andries J, Giral Philippe, Mannarino Elmo, Robertson Christine M, Talmud Philippa J, Hedblad Bo, Hofman Albert, Erdmann Jeanette, Reilly Muredach P, O'Donnell Christopher J, Farrall Martin, Clarke Robert, Franzosi Maria Grazia, Seedorf Udo, Syvänen Ann-Christine, Hansson Göran K, Eriksson Per, Samani Nilesh J, Watkins Hugh, Price Jacqueline F, Hingorani Aroon D, Melander Olle, Witteman Jacqueline C M, Baldassarre Damiano, Tremoli Elena, de Faire Ulf, Humphries Steve E, Hamsten Anders
Abstract excerpt
BACKGROUND: Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. METHODS AND RESULTS: To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT...
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