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Article

Susceptibility Loci for Clinical Coronary Artery Disease and Subclinical Coronary Atherosclerosis Throughout the Life-Course.

Circulation. Cardiovascular genetics - 1 Dec 2015

Salfati Elias, Nandkeolyar Shuktika, Fortmann Stephen P, Sidney Stephen, Hlatky Mark A, Quertermous Thomas, Go Alan S, Iribarren Carlos, Herrington David M, Goldstein Benjamin A, Assimes Themistocles L

Abstract excerpt

BACKGROUND: Recent genome-wide association studies have identified 49 single nucleotide polymorphisms associated with clinical coronary artery disease. The mechanism by which these loci influence risk remains largely unclear. METHODS AND RESULTS: We examined the association between a genetic risk score composed of high-risk alleles at the 49 single nucleotide polymorphisms and the degree of subclinical coronary...

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Identifiers

PMID: 26417035
DOI: 10.1161/CIRCGENETICS.114.001071
PMCID: PMC4824193

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