Article
Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study.
Atherosclerosis - 1 Jun 2013
Zhang Lili, Buzkova Petra, Wassel Christina L, Roman Mary J, North Kari E, Crawford Dana C, Boston Jonathan, Brown-Gentry Kristin D, Cole Shelley A, Deelman Ewa, Goodloe Robert, Wilson Sarah, Heiss Gerardo, Jenny Nancy S, Jorgensen Neal W, Matise Tara C, McClellan Bob E, Nato Alejandro Q, Ritchie Marylyn D, Franceschini Nora, Kao W H Linda
Abstract excerpt
BACKGROUND: A number of genetic variants have been discovered by recent genome-wide association studies for their associations with clinical coronary heart disease (CHD). However, it is unclear whether these variants are also associated with the development of CHD as measured by subclinical atherosclerosis phenotypes, ankle brachial index (ABI), carotid artery intima-media thickness (cIMT) and carotid plaque....
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