Article
Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases.
Pharmacological reports : PR - 1 Aug 2014
Dudarewicz Michał, Rychlik-Sych Mariola, Barańska Małgorzata, Wojtczak Anna, Trzciński Radzisław, Dziki Adam, Skrętkowicz Jadwiga
Abstract excerpt
BACKGROUND: The main types of inflammatory bowel diseases (IBD) are ulcerative colitis (UC) and Crohn's disease (CD). There is evidence that, in addition to immunological and environmental factors, genetic factors also play an important role in the pathogenesis of IBD. Determination of polymorphism of CYP2D6 and NAT2 genes encoding I and II phase enzymes of xenobiotic biotransformation may have clinical value as...
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