Article
Genetic Variants of Pre-microRNAs A-499G(rs3746444) and T-196a2C(rs11614913) with Ulcerative Colitis (UC) and Investigated with Thiopurine-S-Methyltransferase (TPMT) Activity.
Clinical laboratory - 1 Oct 2017
Ghobadi Farideh, Vaisi-Raygani Asad, Bahrehmand Fariborz, Tanhapour Maryam, Kiani Amir, Rahimi Zohreh, Pourmotabbed Tayebeh
Abstract excerpt
BACKGROUND: Abnormal expression and different splicing of miRNAs are involved in several human inflammatory disorders. It has been suggested that gene variants of miRNAs may be associated with increased risk of ulcerative colitis (UC). We aimed to evaluate the association of two SNPs (miRNA-A-499G(rs3746444) and miRNA-T196a2C(rs11614913)) with the risk of UC and monitor their effect on...
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