Article
Common polymorphisms in the microsomal epoxide hydrolase and N-acetyltransferase 2 genes in association with inflammatory bowel disease in the Danish population.
European journal of gastroenterology & hepatology - 1 Mar 2011
Ernst Anja, Andersen Vibeke, Ostergaard Mette, Jacobsen Bent A, Pedersen Inge S, Drewes Asbjørn M, Okkels Henrik, Krarup Henrik B
Abstract excerpt
INTRODUCTION: Chronic inflammatory bowel disease (IBD) is characterized by recurrent inflammation of the intestinal mucosa. Reactive molecules play a central role in altering the intestinal permeability, which may induce or sustain an immune response. Changes in detoxification of substances that causes epithelial damage may confer susceptibility to IBD. Hence, polymorphic enzymes involved in the detoxification...
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