Amsacrine-induced mutations in AS52 cells.

Article

Amsacrine-induced mutations in AS52 cells.

Environmental and molecular mutagenesis - 1 Jan 1998

Ferguson L R, Turner P M, Hart D W, Tindall K R

Abstract excerpt

Amsacrine is an acridine-derived inhibitor of topoisomerase II that intercalates into DNA. We performed a detailed molecular analysis of 6-thioguanine (6-TG)-resistant mutant colonies arising in AS52 cells following Amsacrine treatment. AS52 cells carry a single copy of the bacterial gpt gene, fu...

Topics

Amsacrine
Animals
Antineoplastic Agents
Blotting, Northern
CHO Cells
Cell Line
Cricetinae
Mutagens
Mutation
Polymerase Chain Reaction
Thioguanine

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