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Article

Polymerase chain reaction-based deletion analysis of spontaneous and arsenite-enhanced gpt mutants in CHO-AS52 cells.

Mutation research - 23 Sept 1996

Meng Z, Hsie A W

Abstract excerpt

In this study, we have examined the mutagenicity of sodium arsenite at the xanthine-guanine phosphoribosyltransferase locus (ypt) in a pSV2 gpt-transformed CHO cell line, AS52. Our results provide very weak evidence for arsenite as a gene mutagen because the chemical at high doses and at high cytotoxicity enhances barely a doubling of mutant frequency (MF) and a doubling of the gpt gene deletion frequency...

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Identifiers

PMID: 8841493
DOI: 10.1016/0027-5107(96)00068-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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