Polymerase chain reaction-based deletion analysis of spontaneous and arsenite-enhanced gpt mutants in CHO-AS52 cells.

doi:10.1016/0027-5107(96)00068-1

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Article

Polymerase chain reaction-based deletion analysis of spontaneous and arsenite-enhanced gpt mutants in CHO-AS52 cells.

Mutation research - 23 Sept 1996

Meng Z, Hsie A W

Abstract excerpt

In this study, we have examined the mutagenicity of sodium arsenite at the xanthine-guanine phosphoribosyltransferase locus (ypt) in a pSV2 gpt-transformed CHO cell line, AS52. Our results provide very weak evidence for arsenite as a gene mutagen because the chemical at high doses and at high cyt...

Topics

Animals
Arsenites
Bacterial Proteins
CHO Cells
Cell Line, Transformed
Cricetinae
Escherichia coli Proteins
Genetic Variation
Mutagenicity Tests
Mutagens
Pentosyltransferases
Polymerase Chain Reaction
Proteins
Sequence Deletion
Sodium Compounds

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