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Spontaneous frequency of 6-thioguanine resistant mutants in CHO-AS52 cells after prolonged culturing in the absence of selective agents.

Environmental and molecular mutagenesis - 1 Jan 1990

Li A P

Abstract excerpt

The Escherichia coli xanthine-guanine phosphoribosyl transferase (XPT) containing Chinese hamster ovary (CHO-AS52) cells were studied in our laboratory to evaluate its general applicability in genotoxicity testing of industrial chemicals. Our initial effort was to evaluate the stability of the 6-thioguanine sensitive phenotype. The CHO-AS52 cells were cloned and cultured continuously for over 600 days in the...

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PMID: 2357973
DOI: 10.1002/em.2850150407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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