Spontaneous frequency of 6-thioguanine resistant mutants in CHO-AS52 cells after prolonged culturing in the absence of selective agents.

doi:10.1002/em.2850150407

Back to search

Article

Spontaneous frequency of 6-thioguanine resistant mutants in CHO-AS52 cells after prolonged culturing in the absence of selective agents.

Environmental and molecular mutagenesis - 1 Jan 1990

Li A P

Abstract excerpt

The Escherichia coli xanthine-guanine phosphoribosyl transferase (XPT) containing Chinese hamster ovary (CHO-AS52) cells were studied in our laboratory to evaluate its general applicability in genotoxicity testing of industrial chemicals. Our initial effort was to evaluate the stability of the 6-...

Topics

Animals
Cell Count
Cell Line
Cloning, Molecular
Cricetinae
Culture Media
Drug Resistance
Mutation
Pentosyltransferases
Phenotype
Thioguanine
Time Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.