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[Molecular analysis of spontaneous and arsenite-induced mutations at the gpt locus in Chinese hamster ovary cells].

Yi chuan xue bao = Acta genetica Sinica - 1 Oct 1997

Meng Z, Hsie A W

Abstract excerpt

In this study, we examined the mutagenicity of sodium arsenite at the xathine-guanine phosphoribosyl transferase locus (gpt) in a pSV2 gpt-transformed CHO cell line AS52. The chemical induced a dose-dependent increase of mutant frequency at the locus. Nested PCR analysis revealed that the majority of arsenite-induced AS52 mutants had totally deleted the gpt gene. For the spontaneous, 50 mumol/L arsenite--and 100...

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PMID: 9494292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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