[Molecular analysis of spontaneous and arsenite-induced mutations at the gpt locus in Chinese hamster ovary cells].

Article

[Molecular analysis of spontaneous and arsenite-induced mutations at the gpt locus in Chinese hamster ovary cells].

Yi chuan xue bao = Acta genetica Sinica - 1 Oct 1997

Meng Z, Hsie A W

Abstract excerpt

In this study, we examined the mutagenicity of sodium arsenite at the xathine-guanine phosphoribosyl transferase locus (gpt) in a pSV2 gpt-transformed CHO cell line AS52. The chemical induced a dose-dependent increase of mutant frequency at the locus. Nested PCR analysis revealed that the majorit...

Topics

Animals
Arsenites
Base Sequence
CHO Cells
Cricetinae
DNA
Hypoxanthine Phosphoribosyltransferase
Mutation
Polymerase Chain Reaction

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