Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CRF system, stress, depression and anxiety-insights from human genetic studies.

Molecular psychiatry - 1 Jun 2010

Binder E B, Nemeroff C B

Abstract excerpt

A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. Recently, human genetic studies have provided considerable support to several long-standing hypotheses of mood and anxiety disorders, including the CRF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety Disorders
Share to Corticotropin-Releasing Hormone
Share to CRF Receptor, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to Genetic Association Studies

Share to Models, Biological

Share to Receptors, Corticotropin-Releasing Hormone

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 20010888
DOI: 10.1038/mp.2009.141
PMCID: PMC3666571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CRF system, stress, depression and anxiety-insights from human genetic studies.PMID 20010888Read ↗

The neurobiology of depression: inroads to treatment and new drug discovery.Semantic proximity Read ↗

The Corticotropin-Releasing Factor Family: Physiology of the Stress ResponseSemantic proximity Read ↗

Genetics of stress response and stress-related disordersSemantic proximity Read ↗

Persistent central nervous system effects of an adverse early environment: clinical and preclinical studies.Semantic proximity Read ↗

Corticotropin-releasing factor signaling and visceral response to stressSemantic proximity Read ↗

Unraveling the interaction between stress and genetic risk in psychiatric disorders: Challenges, mechanisms, and new advances.Semantic proximity Read ↗

Early life stress unravels epistatic genetic associations of cortisol pathway genes with depression.Semantic proximity Read ↗

Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor.Semantic proximity Read ↗

HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescentsSemantic proximity Read ↗

Corticotropin-Releasing Factor Family: A Stress Hormone-Receptor System’s Emerging Role in Mediating Sex-Specific SignalingSemantic proximity Read ↗

Hormones and the Stressed BrainSemantic proximity Read ↗

Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.