Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex.

doi:10.1523/JNEUROSCI.3672-13.2014

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Article

Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Mar 2014

Glaser Yi G, Zubieta Jon-Kar, Hsu David T, Villafuerte Sandra, Mickey Brian J, Trucco Elisa M, Burmeister Margit, Zucker Robert A, Heitzeg Mary M

Abstract excerpt

Variations in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been found to interact with stress in modulating excessive alcohol consumption. However, the neural mechanisms through which CRHR1 influences this risk in humans is largely unknown. This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits,...

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Identifiers

PMID: 24623788
DOI: 10.1523/JNEUROSCI.3672-13.2014
PMCID: PMC3951705

Genes

CRHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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