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Article

Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.

Virology - 1 Jun 2014

Mathiesen Christian K, Jensen Tanja B, Prentoe Jannick, Krarup Henrik, Nicosia Alfredo, Law Mansun, Bukh Jens, Gottwein Judith M

Abstract excerpt

Recently, cell culture systems producing hepatitis C virus particles (HCVcc) were developed. Establishment of serum-free culture conditions is expected to facilitate development of a whole-virus inactivated HCV vaccine. We describe generation of genotype 1-6 serum-free HCVcc (sf-HCVcc) from Huh7.5 hepatoma cells cultured in adenovirus expression medium. Compared to HCVcc, sf-HCVcc showed 0.6-2.1 log10 higher...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24928051
DOI: 10.1016/j.virol.2014.03.021
PMCID: PMC4415741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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