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Article

Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.

Proceedings of the National Academy of Sciences of the United States of America - 27 Nov 2012

Li Yi-Ping, Ramirez Santseharay, Jensen Sanne B, Purcell Robert H, Gottwein Judith M, Bukh Jens

Abstract excerpt

Chronic infection with hepatitis C virus (HCV) is an important cause of end stage liver disease worldwide. In the United States, most HCV-related disease is associated with genotype 1 infection, which remains difficult to treat. Drug and vaccine development was hampered by inability to culture patient isolates representing HCV genotypes 1-7 and subtypes; only a recombinant 2a genome (strain JFH1) spontaneously...

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Identifiers

PMID: 23151512
DOI: 10.1073/pnas.1218260109
PMCID: PMC3511766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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