Article
Development of Virus-Like Particles (VLPs) for Hepatitis C Virus genotype 4: a novel approach for vaccine development in Egypt.
BMC biotechnology - 18 Jan 2025
Ali Ahmed A, Azouz Rasha A M, Hussein Nahla A, El-Shenawy Reem, Helmy Naiera M, El-Abd Yasmine S, Tabll Ashraf A
Abstract excerpt
BACKGROUND: Egypt has the highest global prevalence of Hepatitis C Virus (HCV) infection, particularly of genotype 4. The development of a prophylactic vaccine remains crucial for HCV eradication, yet no such vaccine currently exists due to the vaccine development challenges. The ability of Virus-Like Particles (VLPs) to mimic the native virus and incorporate neutralizing and conformational epitopes, while...
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