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Article

Complete replication of hepatitis C virus in cell culture.

Science (New York, N.Y.) - 22 Jul 2005

Lindenbach Brett D, Evans Matthew J, Syder Andrew J, Wölk Benno, Tellinghuisen Timothy L, Liu Christopher C, Maruyama Toshiaki, Hynes Richard O, Burton Dennis R, McKeating Jane A, Rice Charles M

Abstract excerpt

Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc)...

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PMID: 15947137
DOI: 10.1126/science.1114016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15947137-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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