Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complete replication of hepatitis C virus in cell culture.

Science (New York, N.Y.) - 22 Jul 2005

Lindenbach Brett D, Evans Matthew J, Syder Andrew J, Wölk Benno, Tellinghuisen Timothy L, Liu Christopher C, Maruyama Toshiaki, Hynes Richard O, Burton Dennis R, McKeating Jane A, Rice Charles M

Abstract excerpt

Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc). Replication of HCVcc was robust, producing nearly 10(5) infectious units per milliliter within 48 hours. Virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tetraspanin 28
Share to Virion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Centrifugation, Density Gradient

Share to Culture Media, Conditioned

Share to Neutralization Tests

Share to Replicon

Share to Serial Passage

Share to Virus Cultivation

Source

Identifiers

PMID: 15947137
DOI: 10.1126/science.1114016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complete replication of hepatitis C virus in cell culture.PMID 15947137Read ↗

On the history of hepatitis C virus cell culture systems.Semantic proximity Read ↗

Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus.Semantic proximity Read ↗

Robust hepatitis C virus infection <i>in vitro</i>Semantic proximity Read ↗

Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies.Semantic proximity Read ↗

Optimised cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity Read ↗

Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity Read ↗

Efficient initiation of HCV RNA replication in cell culture.Semantic proximity Read ↗

Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.Semantic proximity Read ↗

In Vitro Systems for the Study of Hepatitis C Virus InfectionSemantic proximity Read ↗

Hepatitis C Virus: Assembly and Release of Virus ParticlesSemantic proximity Read ↗

Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.Semantic proximity Read ↗

Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.