Article
Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7.
The Journal of general virology - 1 Oct 2013
Galli Andrea, Scheel Troels K H, Prentoe Jannick C, Mikkelsen Lotte S, Gottwein Judith M, Bukh Jens
Abstract excerpt
Hepatitis C virus (HCV) is an important human pathogen infecting hepatocytes. With the advent of infectious cell culture systems, the HCV particle assembly and release processes are finally being uncovered. The HCV core and NS5A proteins co-localize on cytoplasmic lipid droplets (cLDs) or on the endoplasmic reticulum (ER) at different stages of particle assembly. Current knowledge on assembly and release is...
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