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Article

Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture

15 Apr 2002

Abstract excerpt

The recently developed subgenomic hepatitis C virus (HCV) replicons were limited by the fact that the sequence encoding the structural proteins was missing. Therefore, important information about a possible influence of these proteins on replication and pathogenesis and about the mechanism of virus formation could not be obtained. Taking advantage of three cell culture-adaptive mutations that enhance RNA...

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Identifiers

PMID: 11907240
DOI: 10.1128/jvi.76.8.4008-4021.2002

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