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Article

On the history of hepatitis C virus cell culture systems.

Journal of medicinal chemistry - 13 Mar 2014

Lohmann Volker, Bartenschlager Ralf

Abstract excerpt

HCV infections are a major global health burden. After the identification of the virus in 1989, insights into viral replication and drug development have long been hampered by the lack of efficient cell culture models. Their establishment was an important prerequisite for the development of selective antivirals. This review describes the initial difficulties to achieve HCV replication in cell culture, finally...

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PMID: 24164647
DOI: 10.1021/jm401401n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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