On the history of hepatitis C virus cell culture systems.

Abstract excerpt

HCV infections are a major global health burden. After the identification of the virus in 1989, insights into viral replication and drug development have long been hampered by the lack of efficient cell culture models. Their establishment was an important prerequisite for the development of selective antivirals. This review describes the initial difficulties to achieve HCV replication in cell culture, finally...

Topics

• Cell Culture Techniques
• Hepacivirus
• History, 20th Century
• History, 21st Century
• Mutation
• Virus Replication