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Cell culture-grown hepatitis C virus is infectious <i>in vivo</i> and can be recultured <i>in vitro</i>

16 Feb 2006

Abstract excerpt

Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate and progress in the field has been hampered by the lack of efficient HCV culture systems. By using a recently described HCV genotype 2a infectious clone that replicates and produces infectious virus in cell culture (HCVcc), we...

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PMID: 16484368
DOI: 10.1073/pnas.0511218103

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