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Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution

5 Jun 2014

Abstract excerpt

The myelodysplastic syndromes (MDS) are a group of clonal diseases characterized by inefficient haematopoiesis, increased apoptosis and risk of evolution to acute myeloid leukaemia. Alterations in epigenetic processes, including DNA methylation, histone modifications, miRNA and splicing machinery, are well known pathogenical events in MDS. Although many advances have been made in determining the mutational...

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PMID: 24903747
DOI: 10.1111/bjh.12957

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