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Article

Genetic and epigenetic pathways in myelodysplastic syndromes: A brief overview.

Advances in biological regulation - 1 May 2015

Jhanwar Suresh C

Abstract excerpt

Myelodysplastic syndromes (MDS) are a highly heterogenous group of hematopoietic tumors, mainly due to variable clinical features and diverse set of cytogenetic, molecular genetic and epigenetic lesions. The major clinical features of MDS are ineffective hematopoiesis, peripheral cytopenias, and an increased risk of transformation to acute myeloid leukemias, which in turn is most likely determined by specific...

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Share to Chromatin Assembly and Disassembly
Share to DNA, Neoplasm
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Karyotype

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to RNA Splicing

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Source

Identifiers

PMID: 25499150
DOI: 10.1016/j.jbior.2014.11.002

Genes

ASXL1
BCOR
IDH1
IDH2
KRAS
NRAS
RUNX1
SRSF2
TET2
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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