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Article

The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.

Molecular cancer research : MCR - 1 Aug 2013

Larsson Connie A, Cote Gilbert, Quintás-Cardama Alfonso

Abstract excerpt

UNLABELLED: Over the past few years, large-scale genomic studies of patients with myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have unveiled recurrent somatic mutations in genes involved in epigenetic regulation (DNMT3A, IDH1/2, TET2, ASXL1, EZH2 and MLL) and the spliceosomal machinery (SF3B1, U2AF1, SRSF2, ZRSR2, SF3A1, PRPF40B, U2AF2, and SF1). The identification of these mutations and...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Chromatin
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Neoplasm Recurrence, Local

Share to Spliceosomes

Source

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Identifiers

PMID: 23645565
DOI: 10.1158/1541-7786.MCR-12-0695
PMCID: PMC4123851

Genes

ASXL1
IDH1
SRSF2
TET2
ZRSR2

Provenance

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