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Article

Update on cytogenetic and molecular changes in myelodysplastic syndromes.

Leukemia & lymphoma - 1 Apr 2012

Schlegelberger Brigitte, Göhring Gudrun, Thol Felicitas, Heuser Michael

Abstract excerpt

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and a high propensity to transform to acute myeloid leukemia (AML). In the pathogenesis of the disease, both gene mutations and cytogenetic changes play an important role. The latter have been integrated into prognostic scoring systems including the IPSS (International Prognostic Scoring System) and WPSS (World Health Organization...

Topics

Chromosome Aberrations
Genetic Predisposition to Disease
Humans
Karyotype
Mutation
Myelodysplastic Syndromes
Prognosis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21877899
DOI: 10.3109/10428194.2011.618235

Genes

ASXL1
ETV6
IDH1
RUNX1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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