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Article

Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy

24 Mar 2016

Abstract excerpt

Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal hematopoietic stem cell disorders characterized by cytopenia, ineffective hematopoiesis, and progression to secondary acute myeloid leukemia in high-risk cases. Conventional prognostication relies on clinicopathological parameters supplemented by cytogenetic information. However, recent studies have shown that genetic aberrations also have critical...

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PMID: 27023522
DOI: 10.3390/ijms17040440

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