Article
Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes.
British journal of haematology - 1 Sept 2013
Kulasekararaj Austin G, Mohamedali Azim M, Mufti Ghulam J
Abstract excerpt
The advent of novel genomic sequencing technologies has aided the identification of somatically acquired genetic abnormalities up to 80% of myelodysplastic syndrome (MDS) patients. Novel recurrent genetic mutations in pathways such as RNA splicing, DNA methylation and histone modification and cohesion complexes, underscore the molecular heterogeneity seen in this clinically varied disease. Functional studies to...
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