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Recent advances in myelodysplastic syndromes: Molecular pathogenesis and its implications for targeted therapies.

Cancer science - 1 Apr 2015

Harada Hironori, Harada Yuka

Abstract excerpt

Myelodysplastic syndromes (MDS) are defined as stem cell disorders caused by various gene abnormalities. Recent analysis using next-generation sequencing has provided great advances in identifying relationships between gene mutations and clinical phenotypes of MDS. Gene mutations affecting RNA splicing machinery, DNA methylation, histone modifications, transcription factors, signal transduction proteins and...

Topics

Chromatin Assembly and Disassembly
Core Binding Factor Alpha 2 Subunit
DNA Methylation
Humans
Molecular Targeted Therapy
Mutation
Myelodysplastic Syndromes
RNA Splicing
Signal Transduction
Stem Cells
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25611784
DOI: 10.1111/cas.12614
PMCID: PMC4409874

Genes

RUNX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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