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Article

The genetic basis of myelodysplasia and its clinical relevance.

Blood - 12 Dec 2013

Cazzola Mario, Della Porta Matteo G, Malcovati Luca

Abstract excerpt

Myelodysplasia is a diagnostic feature of myelodysplastic syndromes (MDSs) but is also found in other myeloid neoplasms. Its molecular basis has been recently elucidated by means of massive parallel sequencing studies. About 90% of MDS patients carry ≥1 oncogenic mutations, and two thirds of them are found in individuals with a normal karyotype. Driver mutant genes include those of RNA splicing (SF3B1, SRSF2,...

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Source

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Identifiers

PMID: 24136165
DOI: 10.1182/blood-2013-09-381665
PMCID: PMC3862275

Genes

SRSF2
TET2
ASXL1
CBL
IDH1
KRAS
NRAS
RUNX1
STAG2
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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