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The Genetics of Myelodysplastic Syndromes: Clinical Relevance.

Genes - 27 Jul 2021

Chiereghin Chiara, Travaglino Erica, Zampini Matteo, Saba Elena, Saitta Claudia, Riva Elena, Bersanelli Matteo, Della Porta Matteo Giovanni

Abstract excerpt

Myelodysplastic syndromes (MDS) are a clonal disease arising from hematopoietic stem cells, that are characterized by ineffective hematopoiesis (leading to peripheral blood cytopenia) and by an increased risk of evolution into acute myeloid leukemia. MDS are driven by a complex combination of genetic mutations that results in heterogeneous clinical phenotype and outcome. Genetic studies have enabled the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34440317
DOI: 10.3390/genes12081144
PMCID: PMC8392119

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