A COMT gene haplotype associated with methamphetamine abuse.

doi:10.1097/FPC.0b013e32834a53f9

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Article

A COMT gene haplotype associated with methamphetamine abuse.

Pharmacogenetics and genomics - 1 Nov 2011

Jugurnauth Sarah K, Chen Chih-Ken, Barnes Michael R, Li Tao, Lin Shih-Ku, Liu Hsing-Cheng, Collier David A, Breen Gerome

Abstract excerpt

INTRODUCTION: Methamphetamine (MAMP) use is highly associated with psychiatric disorders with 12-13% of MAMP-dependent patients experiencing psychotic symptoms. Substance abuse and dependence may primarily involve the mesolimbic pathway and dopaminergic brain structures. It follows that dopaminergic genes, particularly COMT (encoding catechol-O-methyltransferase) and its val158met polymorphism (rs4680), are...

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PMID: 21934638
DOI: 10.1097/FPC.0b013e32834a53f9

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COMT

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