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Article

High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers.

American journal of medical genetics - 25 Jul 1997

Vandenbergh D J, Rodriguez L A, Miller I T, Uhl G R, Lachman H M

Abstract excerpt

Allelic variants at the catechol-O-methyltransferase (COMT) locus are candidates to contribute to genetic components of interindividual differences in vulnerability to substance abuse. COMT plays a prominent role in dopaminergic circuits important for drug reward, and COMT alleles encode enzymes...

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Identifiers

PMID: 9259381

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9259381-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers.PMID 9259381Read ↗

Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study.Semantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype.Semantic proximity Read ↗

Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Associations between the COMT rs4680 Gene Polymorphism and Personality Dimensions and Anxiety in Patients with a Diagnosis of Other Stimulants DependenceSemantic proximity Read ↗

Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers.Semantic proximity Read ↗

Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study.Semantic proximity Read ↗

A COMT gene haplotype associated with methamphetamine abuse.Semantic proximity Read ↗

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.Semantic proximity Read ↗

The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence.Semantic proximity Read ↗

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