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Article

The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence.

The American journal of forensic medicine and pathology - 1 Dec 2008

Baransel Isir Aysun Baransel, Oguzkan Sibel, Nacak Muradiye, Gorucu Senay, Dulger Hikmet Ergin, Arslan Ahmet

Abstract excerpt

Cannabis stimulates dopamine release and activates dopaminergic reward neurons in central pathways that lead to enhanced dependence. Catechol-O-methyl transferase (COMT) inactivates amplified extraneuronally released dopamine. A functional polymorphism (COMT Val158Met) resulting in increased enzyme activity has been associated with polysubstance abuse and addiction to heroin and methamphetamine. The aim of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19259017
DOI: 10.1097/PAF.0b013e3181847e56

Genes

COMT

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