Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.

doi:10.1007/s00702-009-0338-2

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Article

Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Feb 2010

Pálmason Haukur, Moser Dirk, Sigmund Jessica, Vogler Christian, Hänig Susann, Schneider Anna, Seitz Christiane, Marcus Alexander, Meyer Jobst, Freitag Christine M

Abstract excerpt

The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. A single nucleotide polymorphism (Val(158)Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. The aim of the present study was to assess the COMT Val(158)Met SNP as a risk factor for...

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PMID: 19946713
DOI: 10.1007/s00702-009-0338-2

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COMT

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